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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ateroskleroz</journal-id><journal-title-group><journal-title xml:lang="ru">Атеросклероз</journal-title><trans-title-group xml:lang="en"><trans-title>Ateroscleroz</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-256X</issn><issn pub-type="epub">2949-3633</issn><publisher><publisher-name>НИИТПМ-филиал ИЦиГ СО РАН</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">ateroskleroz-39</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>БИОХИМИЧЕСКИЕ МАРКЕРЫ ЭНДОТЕЛИАЛЬНОЙ ДИСФУНКЦИИ И ГЕМОСТАЗА ПРИ АТЕРОСКЛЕРОЗЕ И ГЕНЫ, ОТВЕТСТВЕННЫЕ ЗА ИХ РЕГУЛЯЦИЮ</article-title><trans-title-group xml:lang="en"><trans-title>BIOCHEMICAL MARKERS OF ENDOTHELIAL DYSFUNCTION AND HEMOSTASIS IN ATHEROSCLEROSIS AND THE GENES RESPONSIBLE FOR THEIR REGULATION</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Стрюкова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Stryukova</surname><given-names>E. V.</given-names></name></name-alternatives><email xlink:type="simple">stryukova.j@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рагино</surname><given-names>Ю. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Ragino</surname><given-names>Yu. I.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Максимов</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Maksimov</surname><given-names>V. N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ НИИ терапии и профилактической медицины</institution></aff><aff xml:lang="en"><institution>Institute of Internal and Preventive Medicine</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>27</day><month>09</month><year>2019</year></pub-date><volume>13</volume><issue>1</issue><fpage>49</fpage><lpage>56</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Стрюкова Е.В., Рагино Ю.И., Максимов В.Н., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Стрюкова Е.В., Рагино Ю.И., Максимов В.Н.</copyright-holder><copyright-holder xml:lang="en">Stryukova E.V., Ragino Y.I., Maksimov V.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ateroskleroz.elpub.ru/jour/article/view/39">https://ateroskleroz.elpub.ru/jour/article/view/39</self-uri><abstract><p>В обзоре систематизируются современные представления о маркерах эндотелиальной дисфункции и нарушений гемостаза (асимметричный диметиларгинин, эндотелин-1, адгезивные молекулы ICAM, VCAM, аполипопротеины, антитромбин III, рецептор урокиназного активатора плазминогена, ингибитор пути тканевого фактора, фактор свертывания крови VII, фактор свертывания XII, протромбин), ассоциированных с атерогенезом, и о генах, ответственных за их регуляцию.</p></abstract><trans-abstract xml:lang="en"><p>The review systematized modern concepts of markers of endothelial dysfunction and disorders of hemostasis (asymmetric dimethylarginine, endothelin 1, adhesive ICAM and VCAM molecules, apolipoproteins, antithrombin III, receptor of urokinase plasminogen activator, tissue factor pathway inhibitor, blood coagulation factors VII, XII, prothrombin) associated with atherogenesis, and genes responsible for their regulation.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>атеросклероз</kwd><kwd>эндотелиальная дисфункция</kwd><kwd>гемостаз</kwd><kwd>полиморфизмы генов</kwd><kwd>асимметричный диметиларгинин</kwd><kwd>эндотелин-1</kwd><kwd>адгезивные молекулы ICAM</kwd><kwd>аполипопротеины</kwd><kwd>антитромбин III</kwd><kwd>рецептор урокиназного активатора плазминогена</kwd><kwd>ингибитор пути тканевого фактора</kwd><kwd>фактор свертывания крови VII</kwd><kwd>фактор свертывания XII</kwd><kwd>протромбин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>VCAM</kwd><kwd>atherosclerosis</kwd><kwd>endothelial dysfunction</kwd><kwd>hemostasis</kwd><kwd>gene polymorphisms</kwd><kwd>asymmetric dimethylarginine</kwd><kwd>endothelin-1</kwd><kwd>adhesion molecules ICAM</kwd><kwd>apolipoproteins</kwd><kwd>antithrombin III</kwd><kwd>receptor of urokinase plasminogen activator</kwd><kwd>tissue factor pathway inhibitor</kwd><kwd>blood coagulation factor VII</kwd><kwd>XII</kwd><kwd>prothrombin</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Никитин Ю.П., Николаев К.Ю., Рагино Ю.И. и др. 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