aterosklerozАтеросклерозAteroscleroz2078-256X2949-3633НИИТПМ-филиал ИЦиГ СО РАН10.15372/ATER20200307ateroskleroz-388Research ArticleОБЗОРЫREVIEWSГены аполипротеинов APOA5 и APOH как регуляторы метаболизма липопротеиновGenes of APOA5 and APOH apoliproteins as regulators of lipoprotein metabolismШироковаН. С.ShirokovaN. S.

Широкова Нина Сергеевна – студент

630090, г. Новосибирск, ул. Пирогова, 1

630090, Novosibirsk, Pirogov str., 1

shirokovans97@mail.ruМихайловаС. В.MikhailovaS. V.

Михайлова Светлана Владимировна – кандидат биологических наук, научный сотрудник лаборатории молекулярной генетики человека

630090, г. Новосибирск, пр. Академика Лаврентьева, 10

630090, Novosibirsk, Academician Lavrentiev av., 10

mikhail@bionet.nsc.ruИванощукД. Е.IvanoshchukD. E.

Иванощук Динара Евгеньевна – младший научный сотрудник лаборатории молекулярной генетики человека, ФИЦ ИЦиГ СО РАН; научный сотрудник лаборатории молекулярно-генетических исследований терапевтических заболеваний, НИИТПМ – филиал ИЦиГ СО РАН

630090, г. Новосибирск, пр. Академика Лаврентьева, 10

630089, г. Новосибирск, ул. Бориса Богаткова, 175/1

630090, Novosibirsk, Academician Lavrentiev av., 10,

630089, Novosibirsk, Boris Bogatkov str., 175/1

dinara2084@mail.ruШахтшнейдерЕ. В.ShachtshneiderE. V.

Шахтшнейдер Елена Владимировна – кандидат медицинских наук, руководитель сектора изучения моногенных форм распространенных заболеваний человека, ФИЦ ИЦиГ СО РАН; зам. руководителя филиала по научной работе, НИИТПМ – филиал ИЦиГ СО РАН

630090, г. Новосибирск, пр. Академика Лаврентьева, 10

630089, г. Новосибирск, ул. Бориса Богаткова, 175/1

630090, Novosibirsk, Academician Lavrentiev av., 10,

630089, Novosibirsk, Boris Bogatkov str., 175/1

2117409@mail.ruФГАОУ ВО Новосибирский национальный исследовательский государственный университетNovosibirsk State UniversityФГБНУ ФИЦ Институт цитологии и генетики СО РАНFederal Research Center Institute of Cytology and Genetics of SB RASФГБНУ ФИЦ Институт цитологии и генетики СО РАН; НИИ терапии и профилактической медицины – филиал ФГБНУ ФИЦ Институт цитологии и генетики СО РАНFederal Research Center Institute of Cytology and Genetics of SB RAS; Research Institute of Internal and Preventive Medicine – Branch of Federal Research Center Institute of Cytology and Genetics of SB RAS2020031220201635360Copyright © Широкова Н.С., Михайлова С.В., Иванощук Д.Е., Шахтшнейдер Е.В., 20202020Широкова Н.С., Михайлова С.В., Иванощук Д.Е., Шахтшнейдер Е.В.Shirokova N.S., Mikhailova S.V., Ivanoshchuk D.E., Shachtshneider E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ateroskleroz.elpub.ru/jour/article/view/388

Атеросклероз является ведущей причиной развития сердечно-сосудистых заболеваний, приводящих к инвалидизации и смерти пациентов во всем мире. Множество факторов способно влиять на атерогенез, в их числе гипертония, курение, наличие сахарного диабета и воспалительных процессов. Известно, что нарушения обмена холестерина и триглицеридов, вызванные изменением в структуре белков, входящих в состав липопротеинов, ассоциированы с предрасположенностью к гиперлипидемии и атеросклерозу. Несмотря на повышенный интерес к изучению механизмов атерогенеза, многие участники этого процесса остаются не до конца изученными. В данном обзоре рассмотрена структура и функция двух белков, аполипопротеина А5 и аполипопротеина H, в связи с их ассоциацией с нарушением обмена липидов.

Atherosclerosis is main cause of cardiovascular disease leading to disability and death worldwide. Many factors can affect atherogenesis, including hypertension, smoking, diabetes mellitus and inflammatory processes. It is known that disorders of cholesterol and triglycerides It is known, that violation in cholesterol and triglyceride metabolism caused by substitutions in the structure of apolipoproteins are associated with a predisposition to hyperlipidemia and atherosclerosis. Despite the increased interest in the atherogenesis mechanisms, many participants in this process are not fully understood. In this review, we examined the structure and functions of two proteins – apolipoprotein A5 and apolipoprotein H in connection with their association with impaired lipid metabolism.

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The authors declare that there are no conflicts of interest present.