aterosklerozАтеросклерозAteroscleroz2078-256X2949-3633НИИТПМ-филиал ИЦиГ СО РАН10.15372/ATER20200206ateroskleroz-377Research ArticleОБЗОРЫREVIEWSПериваскулярная жировая ткань и атеросклероз: фенотипические особенности и терапевтический потенциалPerivascular adipose tissue and atherosclerosis: phenotypic features and therapeutic potentialhttps://orcid.org/0000-0002-6221-3509БородкинаД. А.BorodkinaD. A.

Бородкина Дарья Андреевна – кандидат медицинских наук, старший научный сотрудник лаборатории исследования гомеостаза отдела диагностики сердечно-сосудистых заболеваний

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alpheia@mail.ruhttps://orcid.org/0000-0002-7780-829XГруздеваО. В.GruzdevaO. V.

Груздева Ольга Викторовна – доктор медицинских наук, заведующий лабораторией исследований гомеостаза отдела диагностики сердечно-сосудистых заболеваний

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o_gruzdeva@mail.ruhttps://orcid.org/0000-0003-3996-3325БеликЕ. В.BelikE. V.

Белик Екатерина Владимировна – младший научный сотрудник лаборатории исследований гомеостаза отдела диагностики сердечно-сосудистых заболеваний

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sionina.ev@mail.ruhttps://orcid.org/0000-0002-6890-3287ДылеваЮ. А.DylevaYu. A.

Дылева Юлия Александровна – кандидат медицинских наук, старший научный сотрудник лаборатории исследования гомеостаза отдела диагностики сердечно-сосудистых заболеваний

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dyleva87@yandex.ruhttps://orcid.org/0000-0002-5642-7746ПаличеваЕ. И.PalichevaE. I.

Паличева Елена Ивановна – старший научный сотрудник лаборатории исследования гомеостаза отдела диагностики сердечно-сосудистых заболеваний

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palichevaelena@rambler.ruФГБНУ НИИ комплексных проблем сердечно-сосудистых заболеванийResearch Institute for Complex Issues of Cardiovascular Diseases2020240720201626372Copyright © Бородкина Д.А., Груздева О.В., Белик Е.В., Дылева Ю.А., Паличева Е.И., 20202020Бородкина Д.А., Груздева О.В., Белик Е.В., Дылева Ю.А., Паличева Е.И.Borodkina D.A., Gruzdeva O.V., Belik E.V., Dyleva Y.A., Palicheva E.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ateroskleroz.elpub.ru/jour/article/view/377

Настоящий обзор посвящен анализу данных по изучению эндокринной функции периваскулярной жировой ткани (ПВЖТ), ее роли в синтезе и секреции гормонов адипоцитов – адипокинов (лептина, адипонектина, резистина). Отражены результаты исследований о возможных системных и локальных эффектах ПВЖТ. Продемонстрированы данные о фенотипической принадлежности ПВЖТ, особенностях ее эндокринной и паракринной функций. Про- и противовоспалительные агенты, выделяемые ПВЖТ, влияют на васкулярное здоровье и вовлечены в патогенетические механизмы развития атеросклероза. Обобщены современные данные о том, что ПВЖТ относится к особым типам жировой ткани с точки зрения как функциональности, происхождения, так и роли в развитии сердечно-сосудистых заболеваний, провоцируемых ожирением. В целом ПВЖТ может рассматриваться в качестве перспективной фармакологической мишени для профилактики сердечно-сосудистых рисков, связанных с этими заболеваниями.

This review is devoted to the analysis of data on the study of the endocrine function of perivascular adipose tissue (PVAT), its role in the synthesis and secretion of adipocyte hormones – adipokines (leptin, adiponectin, resistin). The results of studies on the possible systemic and local effects of PVAT are reflected. Demonstrated data on the phenotypic affiliation of PVAT, the features of its endocrine and paracrine functions. Pro-and anti-inflammatory agents secreted by PVAT affect vascular health and are involved in the pathogenetic mechanisms of the development of atherosclerosis. This review summarizes current evidence that PVAT refers to special types of adipose tissue, in terms of both functionality, origin, and role in the development of cardiovascular diseases caused by obesity. In general, PVAT can be considered as a promising pharmacological target for the prevention of cardiovascular risks associated with these diseases.

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The authors declare that there are no conflicts of interest present.