aterosklerozАтеросклерозAteroscleroz2078-256X2949-3633НИИТПМ-филиал ИЦиГ СО РАН10.15372/ATER20200107ateroskleroz-358Research ArticleОБЗОРЫREVIEWSАссоциация вариантов гена СЕТР с изменениями липидного профиля при различных типах питанияAssociation of cholesterol ester transfer protein gene polymorphism and diet to changes in serum lipid profilehttps://orcid.org/0000-0003-4516-6859ОжигановаН. В.OzhiganovaN. V.

Ожиганова Наталья Владимировна – м.н.с. лаборатории «Сектор изучения моногенных форм распространенных заболеваний», ФИЦ ИЦиГ СО РАН; ординатор по специальности «гастроэнтерология», НИИТПМ – филиал ИЦиГ СО РАН

630090, г. Новосибирск, просп. Академика Лаврентьева, 10; 

630089, г. Новосибирск, ул. Бориса Богаткова, 175/1

630090, Novosibirsk, Academician Lavrentev ave., 10; 

630089, Novosibirsk, Boris Bogatkov str., 175/1

https://orcid.org/0000-0003-4716-876XМустафинаС. В.MustafinaS. V.

Мустафина Светлана Владимировна – д-р мед. наук, в.н.с. лаборатории клинико-популяционных и профилактических исследований терапевтических и эндокринных заболеваний

630089, г. Новосибирск, ул. Бориса Богаткова, 175/1

630089, Novosibirsk, Boris Bogatkov str., 175/1

ШахтшнейдерЕ. В.ShakhtshneiderE. V.

Шахтшнейдер Елена Владимировна – канд. мед. наук, зав. лабораторией «Сектор изучения моногенных форм распространенных заболеваний» ФИЦ ИЦиГ СО РАН; в.н.с. лаборатории молекулярно-генетических исследований терапевтических заболеваний НИИТПМ – филиала ИЦиГ СО РАН

630090, г. Новосибирск, просп. Академика Лаврентьева, 10; 

630089, г. Новосибирск, ул. Бориса Богаткова, 175/1

630090, Novosibirsk, Academician Lavrentev ave., 10; 

630089, Novosibirsk, Boris Bogatkov str., 175/1

shakhtshneyderev@bionet.nsc.ruФГБНУ ФИЦ Институт цитологии и генетики СО РАН; НИИ терапии и профилактической медицины – филиал ФГБУ ФИЦ Институт цитологии и генетики СО РАНFederal Research Center Institute of Cytology and Genetics of SB RAS; Research Institute of Internal and Preventive Medicine – Branch of Federal Research Center Institute of Cytology and Genetics of SB RASНИИ терапии и профилактической медицины – филиал ФГБУ ФИЦ Институт цитологии и генетики СО РАНResearch Institute of Internal and Preventive Medicine – Branch of Federal Research Center Institute of Cytology and Genetics of SB RAS2020250420201615358Copyright © Ожиганова Н.В., Мустафина С.В., Шахтшнейдер Е.В., 20202020Ожиганова Н.В., Мустафина С.В., Шахтшнейдер Е.В.Ozhiganova N.V., Mustafina S.V., Shakhtshneider E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ateroskleroz.elpub.ru/jour/article/view/358

Переносчик эфиров холестерина, кодируемый геном СЕТР, регулирует обратный транспорт холестерина, посредством которого из периферических тканей удаляется его избыток. Обзор посвящен анализу вариантов гена CETP, ассоциированных с изменениями метаболизма при разных типах питания. При изучении ассоциации питания и метаболических изменений у носителей разных вариантов гена CETP большое значение имеют размер выборки, индивидуальные и возрастные особенности обследуемых, длительность наблюдения, а также анализ всего спектра вариантов гена СЕТР.

The cholesterol ester transfer protein regulates cholesterol efflux from peripheral tissues. The cholesterol ester transfer protein is encoded by CETP gene. The review describes the association of CETP gene variants with metabolic changes in different diets. The association of diet and metabolic changes depends on the sample size, individual and age characteristics of the patients, the duration of the observation, and the analysis of the spectrum of the CETP gene variants.

белокпереносящий эфиры холестеринаCETPлипидный профильлипопротеины высокой плотностисредиземноморская диетаcholesterol ester transfer proteinCETPlipid profilehigh density lipoproteinsMediterranean dietReferencesТитов В.Н. Белок, переносящий эфиры холестерина, физико-химические свойства, функция, роль в патогенезе атеросклероза и основания для ингибирования. Заочная академия последипломного образования // Клин. лаб. диагностика, 2014. Т. 59, № 8. С. 29–36.Титов В.Н. Белок, переносящий эфиры холестерина, физико-химические свойства, функция, роль в патогенезе атеросклероза и основания для ингибирования. Заочная академия последипломного образования // Клин. лаб. диагностика, 2014. Т. 59, № 8. С. 29–36.Qiu X., Mistry A., Ammirati M., Chrunyk B.A., Clark R.W., Cong Y., Culp J.S., Danley D.E., Freeman T.B., Geoghegan K.F., Griffor M.C., Hawrylik S.J., Hayward C.M., Hensley P., Hoth L.R., Karam G.A., Lira M.E., Lloyd D.B., McGrath K.M., Stutzman-Engwall K.J., Subashi A.K., Subashi T.A., Thompson J.F., Wang I-K., Zhao H. and Seddon A.P. Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules // Nat. Struct. Mol. Biol. 2007. Vol. 14. P. 106–113. https://doi.org/10.1038/nsmb1197Qiu X., Mistry A., Ammirati M., Chrunyk B.A., Clark R.W., Cong Y., Culp J.S., Danley D.E., Freeman T.B., Geoghegan K.F., Griffor M.C., Hawrylik S.J., Hayward C.M., Hensley P., Hoth L.R., Karam G.A., Lira M.E., Lloyd D.B., McGrath K.M., Stutzman-Engwall K.J., Subashi A.K., Subashi T.A., Thompson J.F., Wang I-K., Zhao H. and Seddon A.P. Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules // Nat. Struct. Mol. Biol. 2007. Vol. 14. P. 106–113. https://doi.org/10.1038/nsmb1197Kanehisa M., Sato Y., Furumichi M., Morishima K., Tanabe M. New approach for understanding genome variations in KEGG // Nucl. Acids Res. 2019. Vol. 47. P. D590–D595.Kanehisa M., Sato Y., Furumichi M., Morishima K., Tanabe M. New approach for understanding genome variations in KEGG // Nucl. Acids Res. 2019. Vol. 47. P. D590–D595.Gudnason V., Kakko S., Nicaud V., Savolainen M.J., Kesaniemi Y.A., Tahvanainen E., Humphries S. Cholesterol ester transfer protein gene effect on CETP activity and plasma high-density lipoprotein in European populations // Eur. J. Clin. Invest. 1999. Vol. 29, N 2. P. 116–128.Gudnason V., Kakko S., Nicaud V., Savolainen M.J., Kesaniemi Y.A., Tahvanainen E., Humphries S. Cholesterol ester transfer protein gene effect on CETP activity and plasma high-density lipoprotein in European populations // Eur. J. Clin. Invest. 1999. Vol. 29, N 2. P. 116–128.Guo S., Yao M., Ding Y., Zhang J., Yan Y., Liu J., Zhang M.Y., Rui D., Niu Q., He J., Guo H., Ma R. Associations of Cholesteryl Ester Transfer Protein TaqIB Polymorphism with the Composite Ischemic Cardiovascular Disease Risk and HDL-C Concentrations. P. A Meta-Analysis // Int. J. Environ. Res. Public Health. 2016. Vol. 13, N 9. P. 882.Guo S., Yao M., Ding Y., Zhang J., Yan Y., Liu J., Zhang M.Y., Rui D., Niu Q., He J., Guo H., Ma R. Associations of Cholesteryl Ester Transfer Protein TaqIB Polymorphism with the Composite Ischemic Cardiovascular Disease Risk and HDL-C Concentrations. P. A Meta-Analysis // Int. J. Environ. Res. Public Health. 2016. Vol. 13, N 9. P. 882.Farid M.A., Azizi F., Hedayati M., Daneshpour M.S., Shamshiri A.R., Siassi F. Association between CETP Taq1B and LIPC -514C/T polymorphisms with the serum lipid levels in a group of Tehran’s population. P. a cross sectional study // Lipids Health Dis. 2010. Vol. 9. P. 96.Farid M.A., Azizi F., Hedayati M., Daneshpour M.S., Shamshiri A.R., Siassi F. Association between CETP Taq1B and LIPC -514C/T polymorphisms with the serum lipid levels in a group of Tehran’s population. P. a cross sectional study // Lipids Health Dis. 2010. Vol. 9. P. 96.Li T.Y., Zhang C., Asselbergs F.W., Qi L., Rimm E., Hunter D.J., Hu F.B. Interaction between dietary fat intake and the cholesterol ester transfer protein TaqIB polymorphism in relation to HDL-cholesterol concentrations among US diabetic men // Am. J. Clin. Nutr. 2007. Vol. 86, N 5. P. 1524–1529.Li T.Y., Zhang C., Asselbergs F.W., Qi L., Rimm E., Hunter D.J., Hu F.B. Interaction between dietary fat intake and the cholesterol ester transfer protein TaqIB polymorphism in relation to HDL-cholesterol concentrations among US diabetic men // Am. J. Clin. Nutr. 2007. Vol. 86, N 5. P. 1524–1529.Carmena-Ramón R., Ascaso J.F., Real J.T., Nájera G., Ordovаs J.M., Carmena R. Association between the TaqIB polymorphism in the cholesteryl ester transfer protein gene locus and plasma lipoprotein levels in familial hypercholesterolemia // Metabolism. 2001. Vol. 50, N 6. P. 651–656.Carmena-Ramón R., Ascaso J.F., Real J.T., Nájera G., Ordovаs J.M., Carmena R. Association between the TaqIB polymorphism in the cholesteryl ester transfer protein gene locus and plasma lipoprotein levels in familial hypercholesterolemia // Metabolism. 2001. Vol. 50, N 6. P. 651–656.Nordestgaard B.G. Triglyceride-rich lipoproteins and atherosclerotic cardiovascular disease. P. new insights from epidemiology, genetics, and biology // Circ. Res. 2016. Vol. 118. P. 547–563.Nordestgaard B.G. Triglyceride-rich lipoproteins and atherosclerotic cardiovascular disease. P. new insights from epidemiology, genetics, and biology // Circ. Res. 2016. Vol. 118. P. 547–563.Gordon T., Castelli W., Hjortland M.C., Kannel W.B., Dawber T.R. High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study // Am. J. Med. 1977. Vol. 62, N 5. P. 707–714.Gordon T., Castelli W., Hjortland M.C., Kannel W.B., Dawber T.R. High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study // Am. J. Med. 1977. Vol. 62, N 5. P. 707–714.Bochem A.E., Kuivenhoven J.A., Stroes E.S. The promise of cholesteryl ester transfer protein, N CETP inhibition in the treatment of cardiovascular disease // Curr. Pharm. Res. 2013. Vol. 19, N 17. P. 3143–3149.Bochem A.E., Kuivenhoven J.A., Stroes E.S. The promise of cholesteryl ester transfer protein, N CETP inhibition in the treatment of cardiovascular disease // Curr. Pharm. Res. 2013. Vol. 19, N 17. P. 3143–3149.Goldberg A.S., Hegele R.A. Cholesteryl ester transfer protein inhibitors for dyslipidemia: focus on dalcetrapib // Drug. Des. Devel. Ther. 2012. Vol. 6. P. 251–259.Goldberg A.S., Hegele R.A. Cholesteryl ester transfer protein inhibitors for dyslipidemia: focus on dalcetrapib // Drug. Des. Devel. Ther. 2012. Vol. 6. P. 251–259.Corella D., Carrasco P., Amiano P. Common cholesteryl ester transfer protein gene variation related to high-density lipoprotein cholesterol is not associated with decreased coronary heart disease risk after a 10-year follow-up in a Mediterranean cohort: Modulation by alcohol consumption // Atherosclerosis. 2010. Vol. 211, N 2. P. 531–538.Corella D., Carrasco P., Amiano P. Common cholesteryl ester transfer protein gene variation related to high-density lipoprotein cholesterol is not associated with decreased coronary heart disease risk after a 10-year follow-up in a Mediterranean cohort: Modulation by alcohol consumption // Atherosclerosis. 2010. Vol. 211, N 2. P. 531–538.Brousseau M.E., Schaefer E.J., Wolfe M.L., Bloedon L.T., Digenio A.G., Clark R.W., Mancuso J.P., Rader D.J. Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol // N. Engl. J. Med. 2004. Vol. 350, N 15. P. 1505–1515.Brousseau M.E., Schaefer E.J., Wolfe M.L., Bloedon L.T., Digenio A.G., Clark R.W., Mancuso J.P., Rader D.J. Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol // N. Engl. J. Med. 2004. Vol. 350, N 15. P. 1505–1515.Arikan G.D., İsbir S., Yilmaz S.G., İsbir T. Characteristics of coronary artery disease patients who have a polymorphism in the cholesterol ester transfer protein, N CETP gene // In Vivo. 2019. 33, N 3. P. 787–792.Arikan G.D., İsbir S., Yilmaz S.G., İsbir T. Characteristics of coronary artery disease patients who have a polymorphism in the cholesterol ester transfer protein, N CETP gene // In Vivo. 2019. 33, N 3. P. 787–792.Plengpanich W., Goff W.L., Poolsuk S., Julia Z., Guérin M., Khovidhunkit W. ETP deficiency due to a novel mutation in the CETP gene promoter and its effect on cholesterol efflux and selective uptake into hepatocytes // Atherosclerosis. 2011. Vol. 216, N 2. P. 370–373.Plengpanich W., Goff W.L., Poolsuk S., Julia Z., Guérin M., Khovidhunkit W. ETP deficiency due to a novel mutation in the CETP gene promoter and its effect on cholesterol efflux and selective uptake into hepatocytes // Atherosclerosis. 2011. Vol. 216, N 2. P. 370–373.Qi Q., Durst R., Schwarzfuchs D., Leitersdorf E., Shpitzen S., Li Y., Wu H., Champagne C.M., Hu F.B., Stampfer M.J., Bray G.A., Sacks F.M., Shai I., Qi L. CETP genotype and changes in lipid levels in response to weight-loss diet intervention in the POUNDS LOST and DIRECT randomized trials // J. Lipid Res. 2015. Vol. 56, N 3. P. 713–721.Qi Q., Durst R., Schwarzfuchs D., Leitersdorf E., Shpitzen S., Li Y., Wu H., Champagne C.M., Hu F.B., Stampfer M.J., Bray G.A., Sacks F.M., Shai I., Qi L. CETP genotype and changes in lipid levels in response to weight-loss diet intervention in the POUNDS LOST and DIRECT randomized trials // J. Lipid Res. 2015. Vol. 56, N 3. P. 713–721.Garcia-Rios A., Alcala-Diaz J.F., Gomez-Delgado F., Delgado-Lista J., Marin C., Leon-Acuсa A., Camargo A., Rodriguez-Cantalejo F., Blanco-Rojo R., Quintana-Navarro G., Ordovas J.M., Perez-Jimenez F., Lopez-Miranda J., Perez-Martinez P. Beneficial effect of CETP gene polymorphism in combination with a Mediterranean diet influencing lipid metabolism in metabolic syndrome patients. P. CORDIOPREV study // Clin. Nutr. 2018. Vol. 37, N 1. P. 229–234.Garcia-Rios A., Alcala-Diaz J.F., Gomez-Delgado F., Delgado-Lista J., Marin C., Leon-Acuсa A., Camargo A., Rodriguez-Cantalejo F., Blanco-Rojo R., Quintana-Navarro G., Ordovas J.M., Perez-Jimenez F., Lopez-Miranda J., Perez-Martinez P. Beneficial effect of CETP gene polymorphism in combination with a Mediterranean diet influencing lipid metabolism in metabolic syndrome patients. P. CORDIOPREV study // Clin. Nutr. 2018. Vol. 37, N 1. P. 229–234.Kalantar Z., Eshraghian M.R., Sotoudeh G., Djalali M., Mansouri A., Alvandi E., Javadi F., Mahmoudi M., Koohdani F. Differences in the interaction between CETP Taq1B polymorphism and dietary fat intake on lipid profile of normolipedemic and dyslipidemic patients with type 2 diabetes mellitus // Clin. Nutr. 2018. Vol. 37, N 1. P. 270–275.Kalantar Z., Eshraghian M.R., Sotoudeh G., Djalali M., Mansouri A., Alvandi E., Javadi F., Mahmoudi M., Koohdani F. Differences in the interaction between CETP Taq1B polymorphism and dietary fat intake on lipid profile of normolipedemic and dyslipidemic patients with type 2 diabetes mellitus // Clin. Nutr. 2018. Vol. 37, N 1. P. 270–275.Shakhtshneider E.Y., Kulikov I.V., Maksimov V.N., Ragino Y.I., Ivanova M.V., Voevoda M.I. CETP gene polymorphism in the caucasian population of West Siberia and in groups contrast by total serum cholesterol levels // Bull. Exp. Biol. Med. 2014. Vol. 157, N 3. P. 364–367.Shakhtshneider E.Y., Kulikov I.V., Maksimov V.N., Ragino Y.I., Ivanova M.V., Voevoda M.I. CETP gene polymorphism in the caucasian population of West Siberia and in groups contrast by total serum cholesterol levels // Bull. Exp. Biol. Med. 2014. Vol. 157, N 3. P. 364–367.Boekholdt S.M., Sacks F.M., Jukema J.W. Shepherd J., Freeman D.J., McMahon A.D., Cambien F., Nicaud V., de Grooth G.J., Talmud P.J., Humphries S.E., Miller G.J., Eiriksdottir G., Gudnason V., Kauma H., Kakko S., Savolainen M.J., Arca M., Montali A., Liu S., Lanz H.J., Zwinderman A.H., Kuivenhoven J.A., Kastelein J.J. Cholesteryl ester transfer protein TaqIB variant, high-density lipoprotein cholesterol levels, cardiovascular risk, and efficacy of pravastatin treatment. P. individual patient meta-analysis of 13677 subjects // Circulation. 2005. Vol. 111, N 3. P. 278–287.Boekholdt S.M., Sacks F.M., Jukema J.W. Shepherd J., Freeman D.J., McMahon A.D., Cambien F., Nicaud V., de Grooth G.J., Talmud P.J., Humphries S.E., Miller G.J., Eiriksdottir G., Gudnason V., Kauma H., Kakko S., Savolainen M.J., Arca M., Montali A., Liu S., Lanz H.J., Zwinderman A.H., Kuivenhoven J.A., Kastelein J.J. Cholesteryl ester transfer protein TaqIB variant, high-density lipoprotein cholesterol levels, cardiovascular risk, and efficacy of pravastatin treatment. P. individual patient meta-analysis of 13677 subjects // Circulation. 2005. Vol. 111, N 3. P. 278–287.Mirmiran P., Esfandiar Z., Hosseini-Esfahani F., Koochakpoor G., Daneshpour M.S., Sedaghati-Khayat B., Azizi F. Genetic variations of cholesteryl ester transfer protein and diet interactions in relation to lipid profiles and coronary heart disease. P. a systematic review // Nutr. Metab. (Lond.). 2017. Vol. 4. P. 77.Mirmiran P., Esfandiar Z., Hosseini-Esfahani F., Koochakpoor G., Daneshpour M.S., Sedaghati-Khayat B., Azizi F. Genetic variations of cholesteryl ester transfer protein and diet interactions in relation to lipid profiles and coronary heart disease. P. a systematic review // Nutr. Metab. (Lond.). 2017. Vol. 4. P. 77.Anagnostopoulou K.K., Kolovou G.D., Kostakou P.M., Mihas C.C., Diakoumakou O., Cokkinos, D.V. Sexassociated effect of CETP and LPL polymorphisms on postprandial lipids in familial hypercholesterolaemia // Lipids Health Dis. 2009. Vol. 8. P. 24.Anagnostopoulou K.K., Kolovou G.D., Kostakou P.M., Mihas C.C., Diakoumakou O., Cokkinos, D.V. Sexassociated effect of CETP and LPL polymorphisms on postprandial lipids in familial hypercholesterolaemia // Lipids Health Dis. 2009. Vol. 8. P. 24.Cheema S.K., Agarwal-Mawal A., Murray C.M., Tucker S. Lack of stimulation of cholesteryl ester transfer protein by cholesterol in the presence of a high-fat diet // J. Lipid Res. 2005. Vol. 46, N 11. P. 2356–2366.Cheema S.K., Agarwal-Mawal A., Murray C.M., Tucker S. Lack of stimulation of cholesteryl ester transfer protein by cholesterol in the presence of a high-fat diet // J. Lipid Res. 2005. Vol. 46, N 11. P. 2356–2366.Corella D., Carrasco P., Fito M., Martínez-Gonzᬠlez M.A., Salas-Salvadу J., Arós F., Lapetra J., Guillén M., Ortega-Azorín C., Warnberg J., Fiol M.А., Ruiz-Gutiérrez V., Serra-Majem L., Martínez J.A., Ros E., Estruch R. Gene-environment interactions of CETP gene variation in a high cardiovascular risk Mediterranean population // J. Lipid Res. 2010. Vol. 51. P. 2798–2807.Corella D., Carrasco P., Fito M., Martínez-Gonzᬠlez M.A., Salas-Salvadу J., Arós F., Lapetra J., Guillén M., Ortega-Azorín C., Warnberg J., Fiol M.А., Ruiz-Gutiérrez V., Serra-Majem L., Martínez J.A., Ros E., Estruch R. Gene-environment interactions of CETP gene variation in a high cardiovascular risk Mediterranean population // J. Lipid Res. 2010. Vol. 51. P. 2798–2807.Gammon C.S., Minihane A.M., Kruger R., Conlon C.A., von Hurst P.R., Jones B., Stonehouse W. TaqIB polymorphism in the cholesterol ester transfer protein, N CETP gene influences lipid responses to the consumption of kiwifruit in hypercholesterolaemic men // Br. J. Nutr. 2014. Vol. 111, N 6. P. 1077–1084.Gammon C.S., Minihane A.M., Kruger R., Conlon C.A., von Hurst P.R., Jones B., Stonehouse W. TaqIB polymorphism in the cholesterol ester transfer protein, N CETP gene influences lipid responses to the consumption of kiwifruit in hypercholesterolaemic men // Br. J. Nutr. 2014. Vol. 111, N 6. P. 1077–1084.Mackay D.S., Eck P.K., Rideout T.C., Baer D.J., Jones P.J. Cholesterol ester transfer protein polymorphism rs5882 is associated with triglyceride-lowering in response to plant sterol consumption // Appl. Physiol. Nutr. Metab. 2015. Vol. 40, N 8. P. 846–849.Mackay D.S., Eck P.K., Rideout T.C., Baer D.J., Jones P.J. Cholesterol ester transfer protein polymorphism rs5882 is associated with triglyceride-lowering in response to plant sterol consumption // Appl. Physiol. Nutr. Metab. 2015. Vol. 40, N 8. P. 846–849.Lottenberg A.M., Nunes V.S., Nakandakare E.R., Neves M., Bernik M., Lagrost L., dos Santos J.E., Quintгo E. The human cholesteryl ester transfer protein I405V polymorphism is associated with plasma cholesterol concentration and its reduction by dietary phytosterol esters // J. Nutr. 2003. Vol. 133, N 6. P. 1800–1805.Lottenberg A.M., Nunes V.S., Nakandakare E.R., Neves M., Bernik M., Lagrost L., dos Santos J.E., Quintгo E. The human cholesteryl ester transfer protein I405V polymorphism is associated with plasma cholesterol concentration and its reduction by dietary phytosterol esters // J. Nutr. 2003. Vol. 133, N 6. P. 1800–1805.Hosseini-Esfahani F., Esfandiar Z., Mirmiran P., Daneshpour M.S., Ghanbarian A., Azizi F. The interaction of cholesteryl ester transfer protein gene variations and diet on changes in serum lipid profiles // Eur. J. Clin. Nutr. 2019. Vol. 73, N 9. P. 1291–1298Hosseini-Esfahani F., Esfandiar Z., Mirmiran P., Daneshpour M.S., Ghanbarian A., Azizi F. The interaction of cholesteryl ester transfer protein gene variations and diet on changes in serum lipid profiles // Eur. J. Clin. Nutr. 2019. Vol. 73, N 9. P. 1291–1298

The authors declare that there are no conflicts of interest present.