aterosklerozАтеросклерозAteroscleroz2078-256X2949-3633НИИТПМ-филиал ИЦиГ СО РАН10.15372/ATER20190211ateroskleroz-351Research ArticleОБЗОРЫREVIEWSИНФЕКЦИИ, ВОСПАЛЕНИЕ И АТЕРОСКЛЕРОЗINFECTIONS, INFLAMMATION AND ATHEROSCLEROSISРешетниковО. В.ReshetnikovO. V.КуриловичС. А.KurilovichS. A.НикитинЮ. П.NikitinYu. P.НИИ терапии и профилактической медицины – филиал ФГБНУ ФИЦ Институт цитологии и генетики СО РАНРоссияResearch Institute of Internal and Preventive Medicine – Branch of Federal Research Institute of Cytology and Genetics of SB RASRussian FederationНИИ терапии и профилактической медицины – филиал ФГБНУ ФИЦ Институт цитологии и генетики СО РАН; ФГБОУ Новосибирский государственный медицинский университет Минздрава РоссииРоссияResearch Institute of Internal and Preventive Medicine – Branch of Federal Research Institute of Cytology and Genetics of SB RAS; Novosibirsk State Medical University of Minzdrav of RussiaRussian Federation2019221220191527888Copyright © Решетников О.В., Курилович С.А., Никитин Ю.П., 20192019Решетников О.В., Курилович С.А., Никитин Ю.П.Reshetnikov O.V., Kurilovich S.A., Nikitin Y.P.This work is licensed under a Creative Commons Attribution 4.0 License.https://ateroskleroz.elpub.ru/jour/article/view/351

Атеросклеротические сердечно-сосудистые заболевания являются, как известно, основной причиной смерти во всем мире. В последние десятилетия показано влияние многих микроорганизмов, участвующих (прямо или косвенно) в провоцировании процесса атерогенеза, включая клеточную адгезию, цитокин-ассоциированные повреждения, выделения реактивных видов кислорода и др. Другие, например вирус гриппа, могут вызывать системное воспаление, которое может повредить сосудистую стенку (например, цитокинами и протеазами). Кроме того, другим косвенным механизмом, посредством которого некоторые инфекционные агенты (такие как Helicobacter pylori, Chlamydia pneumoniae, периодонтальные патогены и др.) влияют на патогенез атеросклероза, является молекулярная мимикрия. Учитывая сложность механизмов, с помощью которых каждый патоген может способствовать развитию и прогрессированию атеросклероза, очевидно, что продолжающиеся исследования и новые данные будут полезны для улучшения нашего понимания инфекционного компонента развития атеросклероза. 

Atherosclerotic cardiovascular diseases are the leading cause of death worldwide. In recent decades, the influence of many microorganisms involved (directly or indirectly) in provoking the process of atherogenesis, including cell adhesion, cytokine-associated damage, release of reactive oxygen species, etc. has been shown. Others, such as the influenza virus, can cause systemic inflammation that can damage vascular wall (for example, by cytokines and proteases). In addition, another indirect mechanism by which some infectious agents (such as Helicobacter pylori, Chlamydia pneumoniae, periodontal pathogens, etc.) that may play a role in the pathogenesis of atherosclerosis is molecular mimicry. Given the complexity of the mechanisms by which each pathogen can contribute to the development and progression of atherosclerosis, it is obvious that ongoing research and new data will be useful for improving our understanding of the infectious component of atherosclerosis.

атеросклерозпатогенезбактериальные и вирусные инфекцииatherosclerosisbacteriavirusespathogenetic mechanismsReferencesCampbell L.A., Rosenfeld M.E. Infection and atherosclerosis development // Arch. Med. Res. 2015. Vol. 46. P. 339–350.Campbell L.A., Rosenfeld M.E. Infection and atherosclerosis development // Arch. Med. Res. 2015. Vol. 46. P. 339–350.O’Connor S., Taylor C., Campbell L.A. et al. Potential infectious etiologies of atherosclerosis: a multifactorial perspective // Emerg. Infect. Dis. 2001. Vol 7. P. 780–788.O’Connor S., Taylor C., Campbell L.A. et al. Potential infectious etiologies of atherosclerosis: a multifactorial perspective // Emerg. Infect. Dis. 2001. Vol 7. P. 780–788.Rosenfeld M.E., Campbell L.A. Pathogens and atherosclerosis: update on the potential contribution of multiple infectious organisms to the pathogenesis of atherosclerosis // Thromb. Haemost. 2011. Vol. 106. P. 858–867.Rosenfeld M.E., Campbell L.A. Pathogens and atherosclerosis: update on the potential contribution of multiple infectious organisms to the pathogenesis of atherosclerosis // Thromb. Haemost. 2011. Vol. 106. P. 858–867.Org E., Mehrabian M., Lusis A.J. Unraveling the environmental and genetic interactions in atherosclerosis: Central role of the gut microbiota // Atherosclerosis. 2015. Vol. 241 (2). P. 387–399.Org E., Mehrabian M., Lusis A.J. Unraveling the environmental and genetic interactions in atherosclerosis: Central role of the gut microbiota // Atherosclerosis. 2015. Vol. 241 (2). P. 387–399.Fabricant C.G., Fabricant J., Litrenta M.M., Minick C.R. Virus-induced atherosclerosis // J. Exp. Med. 1978. Vol. 148 (1). P. 335–340.Fabricant C.G., Fabricant J., Litrenta M.M., Minick C.R. Virus-induced atherosclerosis // J. Exp. Med. 1978. Vol. 148 (1). P. 335–340.Никитская Е.А., Марюхнич Е.В., Саввинова П.П. и др. Вирусы герпеса человека и атеросклероз. Современный взгляд // Креатив. кардиология. 2015. ¹ 2. С. 54–62.Никитская Е.А., Марюхнич Е.В., Саввинова П.П. и др. Вирусы герпеса человека и атеросклероз. Современный взгляд // Креатив. кардиология. 2015. ¹ 2. С. 54–62.Grivel J.C., Ivanova O., Pinegina N., Blank P.S., Shpektor A., Margolis L.B., Vasilieva E. Activation of T lymphocytes in atherosclerotic plaques // Arterioscler. Thromb. Vasc. Biol. 2011. Vol. 31, 12. P. 2929–2937.Grivel J.C., Ivanova O., Pinegina N., Blank P.S., Shpektor A., Margolis L.B., Vasilieva E. Activation of T lymphocytes in atherosclerotic plaques // Arterioscler. Thromb. Vasc. Biol. 2011. Vol. 31, 12. P. 2929–2937.Никитская Е.А., Гривель Ж.-Ш., Иванова О.И. и др. Исследование герпес-вирусной ДНК в коронарных артериях пациентов, умерших в острой стадии инфаркта миокарда // Креатив. кардиология. 2014. ¹ 4. С. 52–64.Никитская Е.А., Гривель Ж.-Ш., Иванова О.И. и др. Исследование герпес-вирусной ДНК в коронарных артериях пациентов, умерших в острой стадии инфаркта миокарда // Креатив. кардиология. 2014. ¹ 4. С. 52–64.Тарасов А.В., Куляшова Л.Б., Желтакова И.Р. и др. Особенности диагностики инфекции, вызванной Chlamydophila pneumoniae, у больных острым коронарным синдромом // Инфекция и иммунитет. 2016. Т. 6, ¹ 1. С. 67–72.Тарасов А.В., Куляшова Л.Б., Желтакова И.Р. и др. Особенности диагностики инфекции, вызванной Chlamydophila pneumoniae, у больных острым коронарным синдромом // Инфекция и иммунитет. 2016. Т. 6, ¹ 1. С. 67–72.Almalki Z.S., Guo J.J. Cardiovascular events and safety outcomes associated with azithromycin therapy: a meta-analysis of randomized controlled trials // Am. Health. Drug. Benefits. 2014. Vol. 7 (6). P. 318–328.Almalki Z.S., Guo J.J. Cardiovascular events and safety outcomes associated with azithromycin therapy: a meta-analysis of randomized controlled trials // Am. Health. Drug. Benefits. 2014. Vol. 7 (6). P. 318–328.Govea-Alonso D.O., Beltrán-López J., SalazarGonzález J.A., Vargas-Morales J., Rosales-Mendoza S. Progress and future opportunities in the development of vaccines against atherosclerosis // Expert. Rev. Vaccines. 2017. Vol. 16, No. 4. P. 337–350. DOI: 10.1080/14760584.2017.1258309.Govea-Alonso D.O., Beltrán-López J., SalazarGonzález J.A., Vargas-Morales J., Rosales-Mendoza S. Progress and future opportunities in the development of vaccines against atherosclerosis // Expert. Rev. Vaccines. 2017. Vol. 16, No. 4. P. 337–350. DOI: 10.1080/14760584.2017.1258309.Yu M., Zhang Y., Yang Z. et al. Association between Helicobacter pylori infection and stroke: a meta-analysis of prospective observational studies // J. Stroke. Cerebrovasc. Dis. 2014. Vol. 23, N 9. P. 2233–2239.Yu M., Zhang Y., Yang Z. et al. Association between Helicobacter pylori infection and stroke: a meta-analysis of prospective observational studies // J. Stroke. Cerebrovasc. Dis. 2014. Vol. 23, N 9. P. 2233–2239.Huang W.S., Tseng C.H., Lin C.L. et al. Helicobacter pylori infection increases subsequent ischemic stroke risk: a nationwide population-based retrospective cohort study // QJM. 2014. Vol. 107, N. 12. P. 969–975.Huang W.S., Tseng C.H., Lin C.L. et al. Helicobacter pylori infection increases subsequent ischemic stroke risk: a nationwide population-based retrospective cohort study // QJM. 2014. Vol. 107, N. 12. P. 969–975.Sharma V., Aggarwal A. Helicobacter pylori: Does it add to risk of coronary artery disease // World. J. Cardiol. 2015. Vol. 7, N 1. P. 19–25.Sharma V., Aggarwal A. Helicobacter pylori: Does it add to risk of coronary artery disease // World. J. Cardiol. 2015. Vol. 7, N 1. P. 19–25.Vijayvergiya R., Vadivelu R. Role of Helicobacter pylori infection in pathogenesis of atherosclerosis // World. J. Cardiol. 2015. Vol. 7, N 3. P. 134–143.Vijayvergiya R., Vadivelu R. Role of Helicobacter pylori infection in pathogenesis of atherosclerosis // World. J. Cardiol. 2015. Vol. 7, N 3. P. 134–143.Chmiela M., Gajewski A., Rudnicka K. Helicobacter pylori vs coronary heart disease - searching for connections // World. J. Cardiol. 2015. Vol. 7, N 4. P. 187–203.Chmiela M., Gajewski A., Rudnicka K. Helicobacter pylori vs coronary heart disease - searching for connections // World. J. Cardiol. 2015. Vol. 7, N 4. P. 187–203.Решетников О.В., Курилович С.А., Никитин Ю.П. Инфекции пародонта и их возможное влияние на развитие атеросклероза и его осложнений // Атеросклероз. 2015. Т. 11, ¹ 1. С. 74–80.Решетников О.В., Курилович С.А., Никитин Ю.П. Инфекции пародонта и их возможное влияние на развитие атеросклероза и его осложнений // Атеросклероз. 2015. Т. 11, ¹ 1. С. 74–80.Chistiakov D.A., Orekhov A.N., Bobryshev Y.V. Links between atherosclerotic and periodontal disease // Exp. Mol. Pathol. 2016. Vol. 100. P. 220–235.Chistiakov D.A., Orekhov A.N., Bobryshev Y.V. Links between atherosclerotic and periodontal disease // Exp. Mol. Pathol. 2016. Vol. 100. P. 220–235.Chou S.H., Tung Y.C., Lin Y.S. et al. Major adverse cardiovascular events in treated periodontitis: a population-based follow-up study from Taiwan // PLoS. One. 2015. Vol. 10, N 6. e0130807.Chou S.H., Tung Y.C., Lin Y.S. et al. Major adverse cardiovascular events in treated periodontitis: a population-based follow-up study from Taiwan // PLoS. One. 2015. Vol. 10, N 6. e0130807.Bokhari S.A., Khan A.A., Butt A.K. et al. Periodontitis in coronary heart disease patients: strong association between bleeding on probing and systemic biomarkers // J. Clin. Periodontol. 2014. Vol. 41, N 11. P. 1048–1054.Bokhari S.A., Khan A.A., Butt A.K. et al. Periodontitis in coronary heart disease patients: strong association between bleeding on probing and systemic biomarkers // J. Clin. Periodontol. 2014. Vol. 41, N 11. P. 1048–1054.Orlandi M., Suvan J., Petrie A. et al. Association between periodontal disease and its treatment, flow-mediated dilatation and carotid intima-media thickness: a systematic review and meta-analysis // Atherosclerosis. 2014. Vol. 236, N 1. P. 39–46.Orlandi M., Suvan J., Petrie A. et al. Association between periodontal disease and its treatment, flow-mediated dilatation and carotid intima-media thickness: a systematic review and meta-analysis // Atherosclerosis. 2014. Vol. 236, N 1. P. 39–46.Chukkapalli S.S., Rivera-Kweh M.F., Velsko I.M. et al. Chronic oral infection with major periodontal bacteria Tannerella forsythia modulates systemic atherosclerosis risk factors and inflammatory markers // FEMS. Pathogens. Disease. 2015. Vol. 73, N 3. P. 1–12Chukkapalli S.S., Rivera-Kweh M.F., Velsko I.M. et al. Chronic oral infection with major periodontal bacteria Tannerella forsythia modulates systemic atherosclerosis risk factors and inflammatory markers // FEMS. Pathogens. Disease. 2015. Vol. 73, N 3. P. 1–12Решетников О.В., Курилович С.А., Никитин Ю.П. Возможная роль вируса гриппа при атеросклерозассоциированных заболеваниях: насколько эффективна превенция? // Атеросклероз. 2012. Т. 8, ¹ 1. С. 27–35Решетников О.В., Курилович С.А., Никитин Ю.П. Возможная роль вируса гриппа при атеросклерозассоциированных заболеваниях: насколько эффективна превенция? // Атеросклероз. 2012. Т. 8, ¹ 1. С. 27–35Veljkovic V., Glisic S., Veljkovic N. et al. Influenza vaccine as prevention for cardiovascular diseases: possible molecular mechanism // Vaccine. 2014. Vol. 32. P. 6569–6575.Veljkovic V., Glisic S., Veljkovic N. et al. Influenza vaccine as prevention for cardiovascular diseases: possible molecular mechanism // Vaccine. 2014. Vol. 32. P. 6569–6575.Ватутин Н.Т., Калинкина Н.В., Лагутенкова О.И., Шевелек А.Н. Поражение сердечно-сосудистой системы при ВИЧ-инфекции // Сердце и сосуды. 2013. Т. 4, ¹ 44. С. 116–122.Ватутин Н.Т., Калинкина Н.В., Лагутенкова О.И., Шевелек А.Н. Поражение сердечно-сосудистой системы при ВИЧ-инфекции // Сердце и сосуды. 2013. Т. 4, ¹ 44. С. 116–122.Barakat M.G., Arora R.R. Coronary artery disease in the human immunodeficiency virus seropositive population // Am. J. Ther. 2016. Vol. 23, N 1. P. e224e231. DOI: 10.1097/MJT.0b013e3182973924.Barakat M.G., Arora R.R. Coronary artery disease in the human immunodeficiency virus seropositive population // Am. J. Ther. 2016. Vol. 23, N 1. P. e224e231. DOI: 10.1097/MJT.0b013e3182973924.Domont F., Cacoub P. Chronic hepatitis C virus infection, a new cardiovascular risk factor? // Liver. Int. 2016. Vol. 36, N 5. P. 621–627. DOI: 10.1111/ liv.13064.Domont F., Cacoub P. Chronic hepatitis C virus infection, a new cardiovascular risk factor? // Liver. Int. 2016. Vol. 36, N 5. P. 621–627. DOI: 10.1111/ liv.13064.Sullivan Z.A., Wong E.B., Ndung’u T. et al. Latent and active tuberculosis infection increase immune activation in individuals co-infected with HIV // EBio. Med. 2015. Vol. 2, N 4. P. 334–340.Sullivan Z.A., Wong E.B., Ndung’u T. et al. Latent and active tuberculosis infection increase immune activation in individuals co-infected with HIV // EBio. Med. 2015. Vol. 2, N 4. P. 334–340.Chung W.S., Lin C.L., Hung C.T. et al. Tuberculosis increases the subsequent risk of acute coronary syndrome: a nationwide population-based cohort study // Int. J. Tuberc. Lung. Dis. 2014. Vol. 18, N 1. P. 79–83.Chung W.S., Lin C.L., Hung C.T. et al. Tuberculosis increases the subsequent risk of acute coronary syndrome: a nationwide population-based cohort study // Int. J. Tuberc. Lung. Dis. 2014. Vol. 18, N 1. P. 79–83.Sessa R., Pietro M.D., Filardo S., Turriziani O. Infectious burden and atherosclerosis: A clinical issue // World. J. Clin. Cases. 2014. Vol. 2, N 7. P. 240– 249.Sessa R., Pietro M.D., Filardo S., Turriziani O. Infectious burden and atherosclerosis: A clinical issue // World. J. Clin. Cases. 2014. Vol. 2, N 7. P. 240– 249.Kountouras J., Polyzos S.A., Zeglinas C., Katsinelos P. Helicobacter pylori-related chronic hepatitis C infection and the risk for cardiovascular disease // Liver. Int. 2016. May 13. doi: 10.1111/liv.13161.Kountouras J., Polyzos S.A., Zeglinas C., Katsinelos P. Helicobacter pylori-related chronic hepatitis C infection and the risk for cardiovascular disease // Liver. Int. 2016. May 13. doi: 10.1111/liv.13161.Elkind M.S. Infectious burden: a new risk factor and treatment target for atherosclerosis // Infect. Disord. Drug. Targets. 2010. Vol. 10, N 2. P. 84–90.Elkind M.S. Infectious burden: a new risk factor and treatment target for atherosclerosis // Infect. Disord. Drug. Targets. 2010. Vol. 10, N 2. P. 84–90.Thomas G.S., Wann L.S., Allam A.H. et al. Why did ancient people have atherosclerosis?: from autopsies to computed tomography to potential causes // Glob. Heart. 2014. Vol. 9, N 2. P. 229–237.Thomas G.S., Wann L.S., Allam A.H. et al. Why did ancient people have atherosclerosis?: from autopsies to computed tomography to potential causes // Glob. Heart. 2014. Vol. 9, N 2. P. 229–237.Finch C.E. Evolution of the human lifespan, past, present, and future: phases in the evolution of human life expectancy in relation to the inflammatory load // Proc. Am. Philos. Soc. 2012. Vol. 156, N 1. P. 9–44.Finch C.E. Evolution of the human lifespan, past, present, and future: phases in the evolution of human life expectancy in relation to the inflammatory load // Proc. Am. Philos. Soc. 2012. Vol. 156, N 1. P. 9–44.Lathe R., Sapronova A., Kotelevtsev Y. Atherosclerosis and Alzheimer - diseases with a common cause? Inflammation, oxysterols, vasculature // BMC. Geriatrics. 2014. Vol. 14. P. 36.Lathe R., Sapronova A., Kotelevtsev Y. Atherosclerosis and Alzheimer - diseases with a common cause? Inflammation, oxysterols, vasculature // BMC. Geriatrics. 2014. Vol. 14. P. 36.Magen E., Bychkov V., Ginovker A., Kashuba E. Chronic Opisthorchis felineus infection attenuates atherosclerosis – an autopsy study // Int. J. Parasitol. 2013. Vol. 43, N 10. P. 819–824.Magen E., Bychkov V., Ginovker A., Kashuba E. Chronic Opisthorchis felineus infection attenuates atherosclerosis – an autopsy study // Int. J. Parasitol. 2013. Vol. 43, N 10. P. 819–824.

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