aterosklerozАтеросклерозAteroscleroz2078-256X2949-3633НИИТПМ-филиал ИЦиГ СО РАН10.15372/ATER20190210ateroskleroz-341Research ArticleОБЗОРЫREVIEWSИСПОЛЬЗОВАНИЕ миРНК В КАЧЕСТВЕ ДИАГНОСТИЧЕСКИХ МАРКЕРОВ ОСТРОГО ИНФАРКТА МИОКАРДА И РЕМОДЕЛИРОВАНИЯ СЕРДЕЧНОЙ МЫШЦЫmiRNA AS DIAGNOSTIC MARKERS OF ACUTE MYOCARDIAL INFARCTION AND HEART MUSCLE REMODELINGИванощукД. Е.IvanoshchukD. E.dinara2084@mail.ruРозановА. С.RozanovA. S.sibiryak.n@gmail.comОрловП. С.OrlovP. S.orlovpavel86@gmail.comМихайловаС. В.MikhaylovaV. S.mikhail@bionet.nsc.ruШахтшнейдерЕ. В.ShakhtshneyderE. V.2117409@mail.ruКручининаМ. В.KruchininaM. V.2117409@mail.ruВоеводаМ. И.VoevodaM. I.mvoevoda@ya.ruФГБНУ ФИЦ Институт цитологии и генетики СО РАН; НИИ терапии и профилактической медицины – филиал ФГБНУ ФИЦ Институт цитологии и генетики СО РАН; ФГАОУ ВО Новосибирский национальный исследовательский государственный университетРоссияFederal Research Institute of Cytology and Genetics of SB RAS; Research Institute of Internal and Preventive Medicine – Branch of Federal Research Institute of Cytology and Genetics of SB RAS; Novosibirsk State UniversityRussian FederationФГБНУ ФИЦ Институт цитологии и генетики СО РАНРоссияFederal Research Institute of Cytology and Genetics of SB RASRussian FederationНИИ терапии и профилактической медицины – филиал ФГБНУ ФИЦ Институт цитологии и генетики СО РАНРоссияResearch Institute of Internal and Preventive Medicine – Branch of Federal Research Institute of Cytology and Genetics of SB RASRussian Federation2019221220191526877Copyright © Иванощук Д.Е., Розанов А.С., Орлов П.С., Михайлова С.В., Шахтшнейдер Е.В., Кручинина М.В., Воевода М.И., 20192019Иванощук Д.Е., Розанов А.С., Орлов П.С., Михайлова С.В., Шахтшнейдер Е.В., Кручинина М.В., Воевода М.И.Ivanoshchuk D.E., Rozanov A.S., Orlov P.S., Mikhaylova V.S., Shakhtshneyder E.V., Kruchinina M.V., Voevoda M.I.This work is licensed under a Creative Commons Attribution 4.0 License.https://ateroskleroz.elpub.ru/jour/article/view/341

Cердечно-сосудистые заболевания, в частности инфаркт миокарда (ИМ), являются одной из самых распространенных причин смертности в мире. На сегодняшний день в стратегии оценки риска инфаркта и постинфарктных осложнений существенную проблему представляют чувствительность и прогностическая ценность современных методов и маркеров, поэтому выявление новых маркеров, обладающих высокой специфичностью и чувствительностью, является актуальной задачей. В последнее время большое внимание уделяется изучению внеклеточных РНК, которые относительно стабильны в биологических жидкостях и циркулируют, в том числе, в кровяном русле. В статье представлен обзор некоторых миРНК (miRNA), которые рассматриваются в качестве потенциальных маркеров для диагностики инфаркта миокарда и предсказания его неблагоприятных последствий.

Cardiovascular diseases, in particular myocardial infarction (MI), are one of the most common causes of death in the world. Today, a significant problem for assessing of MI and post-infarction complications risks is the insufficient sensitivity and prognostic values of modern methods and markers. Therefore, the identification of new markers with high specificity and sensitivity is an important task. Recently, much attention has been paid to the study of extracellular RNAs, which are relatively stable in biological fluids. In this article, we overviewed some miRNAs, which are considered as potential markers for the diagnosis of MI and prediction of its adverse effects.

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The authors declare that there are no conflicts of interest present.