aterosklerozАтеросклерозAteroscleroz2078-256X2949-3633НИИТПМ-филиал ИЦиГ СО РАН10.15372/ATER20190205ateroskleroz-261Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESК ВОПРОСУ ОБ АССОЦИАЦИИ МЕЖДУ ИШЕМИЧЕСКОЙ БОЛЕЗНЬЮ СЕРДЦА И ЖЕЛЧНОКАМЕННОЙ БОЛЕЗНЬЮ (ЭПИДЕМИОЛОГИЧЕСКОЕ ИССЛЕДОВАНИЕ)ASSOCIATION BETWEEN CORONARY HEART DISEASE AND GALLSTONE DISEASE (EPIDEMIOLOGICAL STUDY)ГригорьеваИ. Н.GrigorievaI. N.igrigorieva@ngs.ruРагиноЮ. И.RaginoYu. I.Романоват. И.RomanovaT. I.МалютинаС. К.MalyutinaS. K.НИИ терапии и профилактической медицины – филиал ФГБНУ ФИЦ Институт цитологии и генетики СО РАН; Новосибирский национальный исследовательский государственный университетResearch Institute of Internal and Preventive Medicine – Branch of Federal Research Institute of Cytology and Genetics of SB RAS; Novosibirsk State UniversityНИИ терапии и профилактической медицины – филиал ФГБНУ ФИЦ Институт цитологии и генетики СО РАНResearch Institute of Internal and Preventive Medicine – Branch of Federal Research Institute of Cytology and Genetics of SB RAS2019221220191523238Copyright © Григорьева И.Н., Рагино Ю.И., Романова т.И., Малютина С.К., 20192019Григорьева И.Н., Рагино Ю.И., Романова т.И., Малютина С.К.Grigorieva I.N., Ragino Y.I., Romanova T.I., Malyutina S.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ateroskleroz.elpub.ru/jour/article/view/261

The aim of the study was to evaluate in the epidemiological study the possible association of coronary heart disease (CHD) and gallstone disease (GSD) in women aged 25–64 years and in men aged 35-54 years, and assess the possible impact on it of certain conventional risk factors (body mass index (BMI), dyslipoproteinemia (DLP), the presence of arterial hypertension (AH) and of diabetes mellitus (DM) type 2) in women. In the frame of the WHO “MONICA” programs it was shown, that among the unorganized urban men population (n = 399) there was no significant relationship between the presence of «definite» IHD and GSD: OR = 0.8 (95 % CI 0.1–6.4, p = 0.8). Among the unorganized urban women population (n = 870) a direct association of GSD with a «definite» coronary artery disease was established: OR = 2.0 (95 % CI 1.1–3.4; p < 0.05), which did not depend on the presence or absence of AH (OR = 1.8; 95 % CI 1.01–3.1; p < 0.05), DLP (OR = 1.9; 95 % CI 1.1–3.6; p < 0,05) or DM type 2 (OR = 1.8; 95 % CI 1.03–3.6; p < 0.05), but disappeared when age and BMI were included in the analysis (OR = 1.5; 95 % CI 0,9–2.7; p > 0.05 and OR = 1.6; 95 % CI 0.9–2.9; p > 0.05, respectively).

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