aterosklerozАтеросклерозAteroscleroz2078-256X2949-3633НИИТПМ-филиал ИЦиГ СО РАНateroskleroz-22Research ArticleОБЗОРЫREVIEWSСИСТЕМА ГЕМОСТАЗА И АТЕРОГЕНЕЗSYSTEM OF HEMOSTASIS AND ATHEROGENESISГромовА. А.GromovA. A.gromovcenter@rambler.ruКручининаМ. В.KruchininaM. V.kruchmargo@yandex.ruШварцЯ. Ш.SchwartzY. A.yshschwartz@mail.ruКручининВ. Н.KruchininV. N.kruch@isp.nsc.ruРыхлицкийС. В.RyhlitskyS. V.rhl@isp.nsc.ruФедеральное государственное бюджетное научное учреждение«Научно-исследовательский институт терапии и профилактической медицины»FSBSE «Scientific Research institute of therapy and preventive medicine»Федеральное государственное бюджетное учреждение науки Институт физики полупроводников им. А. В. Ржанова Сибирского отделения Российской академии наукInstitute of Semiconductor Physics, Siberian Branch of the Russian Academy of Sciences2016270920191233960Copyright © Громов А.А., Кручинина М.В., Шварц Я.Ш., Кручинин В.Н., Рыхлицкий С.В., 20192019Громов А.А., Кручинина М.В., Шварц Я.Ш., Кручинин В.Н., Рыхлицкий С.В.Gromov A.A., Kruchinina M.V., Schwartz Y.A., Kruchinin V.N., Ryhlitsky S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ateroskleroz.elpub.ru/jour/article/view/22

Концепция атеросклероза определяет ключевую роль воспаления в возникновении и прогрессировании атеросклероза. Система гемостаза является неотъемлемой частью воспалительной реакции. На всех этапах атерогенеза, начиная с ранних стадий, отмечается участие факторов гемостаза. Наибольший интерес в последние годы привлекают вопросы межклеточного взаимодействия между тромбоцитами и лейкоцитами. Сочетанная оценка лейкоцитарно-тромбоцитарных реакций отражает клиническую и лабораторную картину атеротромбоза при нестабильной стенкардии и инфаркте миокарда. Моноцитарно-тромбоцитарное взаимодействие играет существенную роль в развитии сердечной недостаточности, тромбоциты крови способны индуцировать апоптоз. Эффективность медикаментозной профилактики и терапии антитромботическими препаратами повысится при индивидуальном тестировании риска геморрагических осложнений. Изменение картины атеросклероза, наблюдаемое в последние годы, также требует введения новых подходов в профилактике атеросклероза, усиление защиты эндотелия. Данный обзор посвящен исследованиям, освещающим участие гемостаза в патогенезе атеросклероза.

Atherosclerosis concept defines the key role of inflammation in the occurrence and progression of atherosclerosis. Hemostatic system is an integral part of the inflammatory response. At all stages of atherogenesis, starting from the early stages, there is part of hemostasis factors. In recent years researchers attract most interest to the questions of intercellular interaction between platelets and leukocytes. Combined evaluation of leukocyte-platelet responses reflect the clinical and laboratory picture of atherothrombotic events in unstable angina and myocardial infarction. Monocyte-platelet interaction plays a significant role in the development of heart failure, blood platelets are capable of inducing apoptosis. The individual testing the risk of hemorrhagic complications increase the efficiency of drug prevention and therapy of antithrombotic drugs. Changing the pattern of atherosclerosis observed in recent years, also requires the introduction of new approaches in the prevention of atherosclerosis, enhancing the protection of the endothelium. This review focuses on the research, covering the role of hemostasis in the pathogenesis of atherosclerosis.

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The authors declare that there are no conflicts of interest present.