aterosklerozАтеросклерозAteroscleroz2078-256X2949-3633НИИТПМ-филиал ИЦиГ СО РАН10.52727/2078-256X-2025-21-2-148-155ateroskleroz-1116Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESКоморбидность ожирения и диспепсии у жителей г. Новосибирска в возрасте 35–54 летСomorbidity of obesity and dyspepsia in residents of Novosibirsk aged 35–54 yearshttps://orcid.org/0000-0003-0069-7744ГригорьеваИ. Н.Grigor’evaI. N.

Ирина Николаевна Григорьева, д-р мед. наук, проф., главный научный сотрудник лаборатории гастроэнтерологии

630089, г. Новосибирск, ул. Бориса Богаткова, 175/1

Irina N. Grigor’eva, doctor of medical sciences, professor, chief researcher

175/1, Boris Bogatkov st., Novosibirsk, 630089

https://orcid.org/0000-0002-2470-2133ДенисоваД. В.DenisovaD. V.

Диана Вахтанговна Денисова, д-р мед. наук, главный научный сотрудник лаборатории профилактической медицины

630089, г. Новосибирск, ул. Бориса Богаткова, 175/1

Diana V. Denisova, doctor of medical sciences, chief researcher of the laboratory of preventive medicine

175/1, Boris Bogatkov st., Novosibirsk, 630089

БеляевскаяЕ. А.BelyaevskayaE. A.

Елена Александровна Беляевская, младший научный сотрудник лаборатории профилактической медицины

630089, г. Новосибирск, ул. Бориса Богаткова, 175/1

Elena A. Belyaevskaya, junior researcher of the laboratory of preventive medicine

175/1, Boris Bogatkov st., Novosibirsk, 630089

РахимоваК. О.RakhimovaK. O.

Ксения Олеговна Рахимова, клинический ординатор, Новосибирск

630089, г. Новосибирск, ул. Бориса Богаткова, 175/1

Ksenia O. Rakhimova, clinical resident

175/1, Boris Bogatkov st., Novosibirsk, 630089

МустакимоваР. Р.MustakimovaR. R.

Рузиля Раилевна Мустакимова, клинический ординатор

630089, г. Новосибирск, ул. Бориса Богаткова, 175/1

Ruzilya R. Mustakimova, clinical resident

175/1, Boris Bogatkov st., Novosibirsk, 630089

https://orcid.org/0000-0001-8514-2304РомановаТ. И.RomanovaT. I.

Татьяна Ивановна Романова, канд. мед. наук, старший научный сотрудник лаборатории гастроэнтерологии

630089, г. Новосибирск, ул. Бориса Богаткова, 175/1

Tatiana I. Romanova, candidate of medical sciences, senior researcher of the laboratory of gastroenterology

175/1, Boris Bogatkov st., Novosibirsk, 630089

Научно-исследовательский институт терапии и профилактической медицины – филиал Федерального государственного бюджетного научного учреждения «Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук»РоссияResearch Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of SciencesRussian Federation202509072025212148155Copyright © Григорьева И.Н., Денисова Д.В., Беляевская Е.А., Рахимова К.О., Мустакимова Р.Р., Романова Т.И., 20252025Григорьева И.Н., Денисова Д.В., Беляевская Е.А., Рахимова К.О., Мустакимова Р.Р., Романова Т.И.Grigor’eva I.N., Denisova D.V., Belyaevskaya E.A., Rakhimova K.O., Mustakimova R.R., Romanova T.I.This work is licensed under a Creative Commons Attribution 4.0 License.https://ateroskleroz.elpub.ru/jour/article/view/1116

Сенсорные и моторные функции желудка, включая опорожнение желудка и аккомодацию, приводящие к диспепсии (Д), значительно влияют на потребление энергии, а ожирение характеризуется энергетическим дисбалансом. Однако данные об ассоциации ожирения и Д неоднородны. Цель исследования – оценка распространенности ожирения и Д, ее типов и выявление возможной связи Д с ожирением в популяционной выборке (ПВ) в возрасте 35–54 лет. Материал и методы. В течение 2023–2025 гг. на базе НИИ терапии и профилактической медицины – филиала Институт цитологии и генетики СО РАН проводится обследование случайной репрезентативной выборки лиц 35–54 лет одного из районов г. Новосибирска. В рамках гастроэнтерологического фрагмента обследование ПВ из 192 лиц (92 мужчины и 100 женщин) включало: пол, возраст, индекс массы тела (ИМТ), заполнение шкалы mFSSG (Modified Frequency Scale of the Symptoms of Gastroesophageal Reflux Disease, модифицированная шкала частоты симптомов гастроэзофагеальной рефлюксной болезни) для выявления Д (суммарный счет 6 баллов соответствовал Д). Результаты. Возраст в ПВ лиц с Д и без нее у мужчин и женщин не различался. Распространенность Д в ПВ составила 26,04 % (n = 50), из них доля женщин – 64,00 %, мужчин – 36,00 % (р < 0,05). Распространенность двух вариантов функциональной диспепсии: синдрома болей вэпигастрии – 24,00 %, постпрандиального дистресс-синдрома (ППДС) – 76,00 % (p < 0,05). Распространенность ожирения в ПВ лиц без Д составляла 24,82 %, с Д – 32,00 % (p > 0,05). ИМТ у лиц с ППДС – 27,54 [23,78; 32,96] кг/м2 (медиана [нижний квартиль; верхний квартиль]) превышал ИМТ у лиц с синдромом болей вэпигастрии СБЭ – 23,56 [22,19; 27,02] кг/м2 (р < 0,05). Ожирение ассоциировано с наличием ППДС (rСпирмена= +0,48, р < 0,05). В ПВ не выявлено ассоциации между наличием Д и ожирением, но среди лиц старше 53 лет с ожирением Д отмечена в 11,2 раза чаще, чем у лиц с нормальной массой тела (р = 0,037). Заключение. В ПВ г. Новосибирска 35–54 лет высока распространенность Д, причем у женщин в 1,78 раза выше, чем у мужчин; среди вариантов Д преобладает ППДС. Распространенность ожирения в ПВ среди лиц с Д и без нее не различалась, однако выявлена ассоциация ожирения с Д у лиц старше 53 лет и у лиц с ППДС. 

The sensory and motor functions of the stomach, including gastric emptying and accommodation, leading to dyspepsia (D), significantly affect energy expenditure, and obesity is characterized by an energy imbalance. However, the data on the association of obesity and FD are heterogeneous. Aim: to assess the prevalence of obesity and D, its types, and to identify a possible association of D with obesity in a population sample (PS) aged 35–54 years. Material and methods. During 2023–2025, a random representative sample of 35–54-year-olds from one of the districts of the city is being surveyed on the basis of NIITPM. Novosibirsk. As part of the gastroenterological fragment, the PS examination of 192 persons (92 men and 100 women) included: gender, age, BMI, filling in the mFSSG D scale (a total score of 6 points corresponded to D). The results are presented as Me [Q25; Q75]. Results. The average age in PS in people with/without D, in men and women did not differ. The prevalence of D in PS (n = 192) was 26.04 % (n = 50), in women – 64.00 %, in men – 36.00 % (p < 0.05). The prevalence of two types of FD: epigastric pain syndrome (EPS) is 24.00 %, and postprandial distress syndrome (PРDS) is 76.00 % (p < 0.05). The prevalence of obesity in the PS of people without D was 24.82%, with D – 32.00 % (p > 0.05). The BMI in individuals with PРDS – 27.54 [23.78; 32.96] kg/m2 exceeded the BMI in individuals with EPS – 23.56 [22.19; 27.02] kg/m2 (p < 0.05). Obesity is associated with the presence of PРDS (rSpearmen = +0.48, p < 0.05). In PS, no association was found between the presence of D and obesity, but among people over 53 years of age with obesity, D was observed 11.2 times more often than in people with normal body mass (p = 0.037). Conclusions. In PS in Novosibirsk, 35–54 years old, D is characterized by a high prevalence, and in women it is 1.78 times higher than in men; PPDS dominates in the D patients. The prevalence of obesity in PS in people with and without D did not differ, however, an association of obesity with D was found in people over 53 years and in people with PPDS.

популяциядиспепсияожирениераспространенностьассоциацииpopulationdyspepsiaobesityprevalenceassociationsРабота выполнена в рамках государственного задания по темам «Эпидемиологический мониторинг распространенных терапевтических заболеваний, их факторов риска и осложнений в Сибири для совершенствования подходов к их профилактике и рискометрии», 2024–2028 гг. (FWNR-2024-0002), «Изучение молекулярно-генетических и молекулярно-биологических механизмов развития распространенных терапевтических заболеваний в Сибири для совершенствования подходов к их ранней диагностике и профилактике», 2024– 2028 гг. 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The authors declare that there are no conflicts of interest present.